Reading on the web. Open in the Thier app for the full interactive version, progress tracking, and XP.

Open

Building Your Stack

1-minute read 35 XP in app 6 cards

A research-backed longevity stack

Based on the protocols of leading longevity researchers (Attia, Huberman, Sinclair), here's a tiered approach to supplementation.

3 tiers of evidence-based stacks

Try in app

The 3-tier approach

See how to build your supplement stack progressively.

This step is hands-on. Open the Thier app to try the full interaction.

Fact

Tier 3 supplements — be honest about the data

NMN, NR, resveratrol, spermidine, urolithin A, fisetin — all have promising mechanistic data and most are safe at typical doses. But human longevity outcomes are still 'TBD' for nearly all of them. NAD+ precursors raise blood NAD+ measurably; whether this translates to meaningful longevity benefit in healthy humans is the open question. Take Tier 3 with realistic expectations: small probability of large benefit, modest cost.

TBD human longevity outcomes

Try in app

What top researchers actually take

Quick survey — composite of public stacks (Attia, Huberman, Sinclair, Kaeberlein 2024).

This step is hands-on. Open the Thier app to try the full interaction.

Tap to reveal

What to skip

Tap each — popular but evidence-thin.

Tap each tile to reveal the detail.

Takeaway

Key Takeaway

Start with Tier 1 (D3, Omega-3, Magnesium) after bloodwork. Add Tier 2 if needed. Tier 3 is optional and experimental. Always prioritize food quality first.

Track your progress

Read the cards above, then mark this lesson complete to track your progress.

Open in app for XP

Up next