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Rapamycin & Metformin

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The most promising longevity drugs

Two existing drugs — rapamycin and metformin — have shown remarkable anti-aging effects in studies. Both are already FDA-approved for other conditions.

2 drugs in longevity trials

Fact

Rapamycin: the mTOR inhibitor

Discovered in Easter Island soil, rapamycin inhibits mTOR — the growth pathway that accelerates aging when chronically active. It extends lifespan in every organism tested.

25% lifespan extension in mice

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Rapamycin's journey

Trace the remarkable history of rapamycin.

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Rapamycin vs Metformin

Compare these two longevity drug candidates.

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True or false

True or False

Metformin is only useful for people with diabetes.

Metformin's anti-aging benefits only apply to diabetics

Diabetics on metformin live longer than non-diabetics not taking it. The TAME trial is studying its anti-aging effects in healthy people.

Select all that apply

Which of these are real, published effects of rapamycin?

Select every confirmed biological effect.

Rapamycin inhibits mTOR, which triggers autophagy and has extended lifespan in every mammal tested. It does NOT directly repair DNA, nor has it been shown to cure Alzheimer's in humans.

Insight

The TAME trial

TAME (Targeting Aging with Metformin) is the first FDA-approved clinical trial to test a drug specifically for aging. If successful, it could change how we regulate anti-aging medicine.

3,000 participants in the TAME trial

Takeaway

Key Takeaway

Rapamycin and metformin are the most promising longevity drugs in clinical research. Both target fundamental aging pathways, but self-medicating is risky — wait for trial results.

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