NAD+ & Sirtuins
The fuel of cellular repair
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme in every cell. It powers DNA repair, energy production, and anti-aging sirtuins — but levels drop 50% by middle age.
NAD+ decline over time
See how NAD+ levels change across your lifetime.
This step is interactive — open the Thier app to try it.
Sirtuins: the longevity genes
Sirtuins (SIRT1-7) are enzymes that protect against aging by repairing DNA, silencing inflammatory genes, and boosting mitochondria. They require NAD+ as fuel to function.
Match the sirtuin
Match each sirtuin to its primary function.
This step is interactive — open the Thier app to try it.
NMN vs NR: supplement comparison
Compare the two main NAD+ precursor supplements.
This step is interactive — open the Thier app to try it.
Myth or Fact?
Swipe left for FACT, right for MYTH.
This step is interactive — open the Thier app to try it.
Key Takeaway
NAD+ is the master fuel for cellular repair. Exercise, fasting, and precursor supplements (NMN/NR) may help maintain levels, but human longevity data is still emerging.