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The Supplement Tier List

6-minute read 30 XP in app 6 cards

Most supplements are a waste of money

The supplement industry is worth $170B but only a handful have strong evidence for longevity. We'll separate the proven from the overhyped.

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Tier list: evidence ranking

Swipe left for STRONG EVIDENCE, right for WEAK/NO EVIDENCE.

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Match the supplement to its benefit

Connect each evidence-based supplement to its primary role.

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Fact

Test before you swallow

Vitamin D and B12 deficiencies are common; iron and B-complex needs vary widely; calcium is often over-supplemented (excess linked to vascular calcification). A simple blood panel — 25-OH Vit D, B12, ferritin, magnesium-RBC, homocysteine — costs less than 2 months of generic supplements and tells you exactly what (if anything) you need. Skip the multivitamin; targeted supplementation always wins.

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Daily timing of common supplements

Some are best with meals, some on an empty stomach, some at night.

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Takeaway

Key Takeaway

The 'essential 4': Vitamin D, Omega-3, Magnesium, and Creatine. These have the strongest evidence base. Test, don't guess — get bloodwork first.