Building Your Stack
A research-backed longevity stack
Based on the protocols of leading longevity researchers (Attia, Huberman, Sinclair), here's a tiered approach to supplementation.
The 3-tier approach
See how to build your supplement stack progressively.
This step is interactive — open the Thier app to try it.
Tier 3 supplements — be honest about the data
NMN, NR, resveratrol, spermidine, urolithin A, fisetin — all have promising mechanistic data and most are safe at typical doses. But human longevity outcomes are still 'TBD' for nearly all of them. NAD+ precursors raise blood NAD+ measurably; whether this translates to meaningful longevity benefit in healthy humans is the open question. Take Tier 3 with realistic expectations: small probability of large benefit, modest cost.
What top researchers actually take
Quick survey — composite of public stacks (Attia, Huberman, Sinclair, Kaeberlein 2024).
This step is interactive — open the Thier app to try it.
What to skip
Tap each — popular but evidence-thin.
This step is interactive — open the Thier app to try it.
Key Takeaway
Start with Tier 1 (D3, Omega-3, Magnesium) after bloodwork. Add Tier 2 if needed. Tier 3 is optional and experimental. Always prioritize food quality first.